|Drug Name||GPCR-targeted Project 018|
Frizzled 4 (FZD4) belongs to the frizzled receptors family. It is a receptor for Wnt proteins, which can activate both Wnt/β-catenin canonical and Wnt/Ca2+ non canonical pathways. FZD4 plays an important role in retinal vascularization by binding Norrin ligand, a Wnt-unrelated growth factor, and activating the β-catenin signaling pathway. In addition, dysregulation of FZD4 expression has been reported in different type of cancers.
|Target||Frizzled 4 (FZD4)|
|Drug Modality||Monoclonal antibody|
|Indication||Familial exudative vitreoretinopathy; Cancers|
|Mechanism of Action||Frizzled 4 modulators|
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