Drug Name | GPCR-targeted Project 018 |
Description |
Frizzled 4 (FZD4) belongs to the frizzled receptors family. It is a receptor for Wnt proteins, which can activate both Wnt/β-catenin canonical and Wnt/Ca2+ non canonical pathways. FZD4 plays an important role in retinal vascularization by binding Norrin ligand, a Wnt-unrelated growth factor, and activating the β-catenin signaling pathway. In addition, dysregulation of FZD4 expression has been reported in different type of cancers. |
Target | Frizzled 4 (FZD4) |
Drug Modality | Monoclonal antibody |
Indication | Familial exudative vitreoretinopathy; Cancers |
Product Category | Biologic |
Mechanism of Action | Frizzled 4 modulators |
Status | Preclinical |
Patent | Granted |
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