The glucagon receptor (GCGR) is a 62 kDa peptide activated by glucagon and is a member of the G-protein coupled family of receptors. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP.
A fully human antibody that specifically binds to GCGR is being developed for the treatment of metabolic disorders including hyperglycemia, type 1 and type 2 diabetes mellitus.
Target
Glucagon receptor (GCGR)
Drug Modality
Monoclonal antibody
Indication
Diabetes; Hyperglycemia
Product Category
Biologic
Mechanism of Action
Glucagon receptor antagonists
Status
Preclinical
Patent
Granted
More Detail Available Upon Request
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