|Drug Name||GPCR-targeted Project 004|
Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as parathyroid hormone 1 receptor (PTH1R) is a member of the B GPCR family and is the primary receptor of two ligands, parathyroid hormone (PTH) and parathyroid related protein (PTHrP). Hypercalcemia can occur when elevated levels of PTH, as seen in primary hyperparathyroidism (PHPT), or elevated levels of PTHrP, as seen in humoral hypercalcemia of malignancy (HHM), lead to excessive activation of the PTH1R. A monoclonal antibody against PTH1R is being developed to reverse hypercalcemia in these conditions.
|Target||Parathyroid hormone 1 receptor (PTH1R)|
|Drug Modality||Monoclonal antibody|
|Mechanism of Action||PTH1R antagonists|
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